Detecting purely epistatic multi-locus interactions by an omnibus permutation test on ensembles of two-locus analyses

An omnibus permutation test on ensembles of two-locus analyses can detect pure epistasis and genetic heterogeneity in genome-wide association studies

This article presents the ability of an omnibus permutation test on ensembles of two-locus analyses (2LOmb) to detect pure epistasis in the presence of genetic heterogeneity. The performance of 2LOmb is evaluated in various simulation scenarios covering two independent causes of complex disease where each cause is governed by a purely epistatic interaction. Different scenarios are set up by var...

EPISTACY: A SAS Program for Detecting Two-Locus Epistatic Interactions Using Genetic Marker Information

Epi2Loc: an R package to investigate two-locus epistatic models.

Epistasis is a growing area of research in genome-wide studies, but the differences between alternative definitions of epistasis remain a source of confusion for many researchers. One problem is that models for epistasis are presented in a number of formats, some of which have difficult-to-interpret parameters. In addition, the relation between the different models is rarely explained. Existing...

Some properties of two-locus systems with epistatic selection.

EpiPen: an R package to investigate two-locus epistatic models - retraction.

The paper ‘EpiPen: An R Package to Investigate Two-Locus Epistatic Models’ has been retracted at the authors’ request in light of their decision to change the name of their research software to Epi2loc to avoid confusion with the EpiPen R © Trademarks owned by Mylan Inc. The authors plan to republish the article under a different title in a forthcoming issue and apologise for any inconvenience ...